PHARMACEUTICAL TRANSDERMAL PATCH MANUFACTURING

US-Bachem transdermal technology offers distributors an attractive alternative to oral drug delivery, as it provides a non-invasive route for drug administration, ensuring predictable drug plasma levels and improved patient compliance. All our products are available as transdermal patches, contract-manufactured in adhesive type, which are pharmaceutical forms that deliver an active ingredient through the transdermal route. They consist of a support layer, an adhesive matrix containing the active ingredient, and a release layer that is discarded when the product is applied to the skin.

• Transdermal topical drug products
• Minoxidil hair loss treatment patches
• Dark eye circles and targeted facial spots
• Acne skincare and even tone chemical peels
• Fast wrinkle eraser and facial tightening
• Suitable for all skin types of allergy-free hydrogels

.Our customized formulations range from Acne treatment, Wrinkles, Stretchmarks, Vitiligo, Scar, Rosacea, Hair loss treatment patches for targeted bald areas and patches for chemical peels. We offer topical patches in doses ranging from 10 mg to 100 mg, with adhesives that are flexible, breathable, and removable.

US-Bachem is an ISO 13485-certified contract manufacturer of hydrogels and transdermal patches, including pharmaceutical and cosmetic products, as well as transdermal patches with additives. We work with customers whose concepts are in all stages of development, from conceptual through full production.  We help customers create prototype samples, manufacture complete product lines, and warehouse and direct-ship products to fulfillment centers. We work with companies to design and manufacture small and large transdermal and topical patch die cuts that meet the most stringent health and safety standards. We work with both small start-up companies and large, well-established companies to help them bring their medicinal patches to market.

.Product Development

We offer customized product development, prototyping, and stability testing capabilities. We will help design your product to be manufacturable and cost effective and conduct extensive testing procedures for your product to guarantee efficacy and active ingredients dermal delivery and develop a new formula from scratch or change our existing liquid formula to custom hydrogel or hydrocolloid patch, and integrated other ingredients such as antibacterial agents, cosmetic agents, Minoxidil, menopausal aid, pain killers, active pharmaceuticals, and your choices.

.How We Manufacture Medicinal Patches

The production of transdermal patches is a continuous process that consists of 3 stages that reflect how delicate and specific the production of this niche pharmaceutical form. The process consists of the following stages:

• Mixing of the active ingredients
• Coating, Drying and Laminating
• Die-cutting and Packaging.

.Mixing

It represents the beginning of the manufacturing process, and its objective is to achieve the integration of the active and non-active ingredients that make up the formulation. The first step is to fractionate and weigh each of the materials that will be part of the mixture, as specified in the production methodology.

At this stage, it is crucial to control the correct dissolution and dispersion of the components to ensure the homogeneity of the adhesive mixture, necessary for accurate dosage and to guarantee that all units produced are effective and safe due to the controlled release of the active ingredient.

Coating, Drying, and Laminating

Once the mixture is obtained, the following process consists of three sub-stages: first is the coating, which is a continuous process where the mixture is uniformly dispensed on the release liner, then both components go through various drying stations to evaporate the volatile components of the mix, to obtain the “adhesive mixture”.

Finally, both components are joined at the exit of the drying stations with the backing film, thereby forming the multilayer system that constitutes the transdermal system. At this stage, it is vital to control the weight of the adhesive matrix dispensed per unit area and the adhesive properties of the matrix, that way, a correct adhesion of the patch at the place of application and an accurate dosage of the drug is guaranteed, and consequently the safety, efficiency, and quality of the drug.

.Die-Cutting and Packaging

The next and last process is the die- cutting and packaging of the transdermal patches. At this stage, the shape of the patch is determined, with the surface established according to the dose. This process involves die-cutting the layers obtained in the previous step, where several cuts are typically made, including one for easy detachment. This allows the patient to open the patch and then apply it to a safer and more practical area of the skin.

The three stages of transdermal patch production require specific adjustments associated with experience; this is one of the most pharmaceutical forms available in the industry. This is why, if your company is considering working on a transdermal patch development and manufacturing project, it is crucial to work with a professional and experienced partner who can demonstrate sufficient knowledge to ensure the necessary quality of this production.